How To Feel Better Now: Endocannabinoids, Cannabinoids and ECS Balance Control

Balance is a term we frequently encounter in health and wellness, but nowhere is it more crucial than within our Endocannabinoid System (ECS). As a cannabinoid researcher, I’ve observed firsthand the remarkable ways the ECS maintains this equilibrium, or ‘tone’, and the pivotal role of endocannabinoids in this process. Our body produces these substances to maintain the balance of our other bodily systems, a harmony known as homeostasis. Homeostasis is not easy to gain, but it’s often referred to in a way that seems instant, especially in advertising.

The ECS is an intricate network of receptors found throughout our body. It regulates sleep, appetite, pain, and immune response. But it doesn’t end or even start there; endocannabinoids are crucial in fertility, pregnancy, and childbirth. Endocannabinoids, such as Anandamide and 2-AG, are naturally occurring compounds that activate CB1 and CB2 receptors, among other receptor systems in the body.

Action and Circulation of Endocannabinoids:

They have significant actions in our body that we do not gain from plant-derived cannabinoids like CBGa, THC, and CBD – but research does support that some endocannabinoids help the ECS produce more and engage more of them into the system, there’s a difference between having them and circulation of them – it gets complex. Most want to know the fix when they can no longer feel THC the way they did in medicating or in simply getting high, which is a form of medicating.

But there’s so much more to it; for that reason, I love to teach about the ECS and how we can balance it in all kinds of ways, opting to take a wake and walks instead of wake and bake. Using acidic and other-than-THC Sunshine cannabinoids, as I call them – they get me going, and if I do use some THC during the day, It’s not stoned’ high; it’s a feeling of medication.

Maintaining an Endocannabinoid Balance is critical for all Cannabis users, but many ask, “What does this mean”? Most are reading blogs and posts online about taking Tolerance breaks when THC doesn’t work so well anymore; few are learning how to Get Balanced, which is a concept to gain Endocannabinoid Balance Control. Tolerance breaks starve a system in need of attention instead of being abandoned; the ‘breaks’ were researched and created for those who were inpatient and in drug abuse centers in which Cannabis was one of the drugs they used, rarely solo.

Endocannabinoid Balance – A Quick Definition

There’s a critical point at which the receptors in our body made for Endocannabinoids begin to be dysfunctional. When this happens, the equillibrium of our body gets disrupted in ways now seen in Pubmed studies, and there are so many maladies it’s impossible to list. This situation is witnessed far more with the millions who use THC – and even more with a crowd using analogs of THC like Delta 8, 10, and other exciting creations that fire up the ECS – but haven’t been studied much yet.

Those who have smoked THC Cannabis for quite some time build up what most call a “High THC Tolerance” when, indeed, it’s a type of ECS Dysfunction. One in which the use of external or plant cannabinoids has diminished the ability of the internal system to work, and in some cases, even causing people to get sick after consuming too much. Then this subtype takes a break and tries again without doing much work on the system – or examining diet supplements other than Cannabinoids and exercise.

ECS Balance

Endocannabinoid Balance is complex, but we can start gaining the proper tones of different endocannabinoids by focusing our diet and supplements on rare and not-so-rare amino acids. When our body gains a better tone to the endocannabinoid system, far more receptors are available, and all endocannabinoids start to become present and functioning. Their small counterparts in the endocannabinoid class also move about our bodies, helping us in crisis and creating who we are as people.

How we think, react, tone, and even speak are determined by a network of fascinating and intricate neuroreceptors and the many substances that our body makes from our diets, supplements, sun exposure, exercise, and more. This system, generally overlooked in any medical exam, is intricate to all other systems treated in healthcare. A gap has led researchers all over the planet down various rabbit holes; mine has been known as ECS Balance Control.

ECS Balance Control

A finding turned into a concept that has been improved over the past five years: a way for humans to create endocannabinoids from everything, from what we hear to what we feel, eat, and see. We can also lose them in the same ways, but we all have various degrees of control. Part of that has included multiple plants, not all from hemp or Cannabis, in creating a plethora of movement within, using myself as a guinea pig.

It’s a perfect world concept often obtained with nature – but not synthetics. The rise of the semi-synthetic Delta 8 was pivotal in my in-depth research on ECS Balance Control and how to ‘Get Balanced,’ far before the trademarking of both names.

CBGa, or Cannabigerolic acid, is often called the ‘mother of all cannabinoids’. It is a precursor to these compounds and is crucial in establishing a balanced ECS tone. In my vast experience, CBGa, especially combined with CBD and even CBG, has been particularly effective, which research supports for individuals seeking to enhance their ECS function without the psychoactive effects of THC.

But the right supplements are needed, and most people don’t know what to get. So, I’ve been working on this Get Balanced Research initiative and a product line in the background to use in it in 2025. The products will be a replica of my stronghold at home but put together in one place with one name for one reason – to enhance how our Endocannabinoid System functions.

Back to the Can’t Get High subject:

Interestingly, for those with a high tolerance to THC, replacing the traditional ‘T Break’ (a break from THC to reduce tolerance) with a focus on enhancing the endocannabinoid tone can be beneficial. Ingesting cannabinoids – most significantly, their precursor CBGa can potentially restore the sensitivity of the ECS receptors, potentially allowing for a more pronounced effect from THC when used.

In essence, nurturing the endocannabinoid tone could be a more sustainable approach to achieving the desired effects from cannabinoids rather than cycling through periods of heavy consumption and complete abstinence. The future of cannabinoid research and therapy lies in understanding and manipulating this tone to promote health and well-being.

How complex are the Endocannabinoids I Research? Very, here’s an extremely Brief Breakdown:

Anandamide (AEA)

What it is: The “bliss molecule” – a primary endocannabinoid.
How it works: Binds mainly to CB1 receptors, like THC.
Why it matters: Helps control mood, memory, appetite, sleep, and pain.

2-Arachidonoylglycerol (2-AG)

What it is: The most abundant endocannabinoid in the brain.
How it works: Activates both CB1 and CB2 receptors.
Why it matters: Plays a central role in inflammation, immune response, and ECS tone.

1-Arachidonoylglycerol (1-AG)

What it is: A positional isomer of 2-AG.
How it works: Weaker activation of CB receptors, but still present in ECS signaling.
Why it matters: May assist in fine-tuning endocannabinoid activity alongside 2-AG.

3-Arachidonoylglycerol (3-AG)

What it is: Another isomer of 2-AG, less understood.
How it works: Likely a breakdown product with limited receptor activity.
Why it matters: Could influence metabolic balance or act as a reservoir for ECS activity.

2-Arachidonyl glyceryl ether (2-AGE / Noladin Ether)

Works like: AEA and 2-AG, with CB1 activation.
Bonus: May promote neuroprotection and appetite regulation.

Oleamide

Known for: Building up during sleep deprivation.
Effect: Promotes sleep and calmness, interacts with CB1 and serotonin.

Oleoylethanolamide (OEA)

Doesn’t bind CB1/CB2, but activates PPAR-alpha.
Effect: Suppresses appetite and promotes fat metabolism.

Virodhamine (O-AEA)

CB1 antagonist, CB2 agonist — counters Anandamide.
Effect: Helps balance ECS tone, especially in the cardiovascular system.

Docosatetraenoylethanolamide (DEA / DTEA)

Less studied, but shows neuroprotective and anti-inflammatory effects.
Family: N-acylethanolamines like AEA.

Stearoylethanolamide (SEA)

Non-cannabinoid binding, but may reduce inflammation and assist cell repair.
Pathway: Likely via PPAR receptors and other cell targets.

Wow, that’s a lot to take in, isn’t it? All this time everyone has been teaching you about what they sell, not what your body makes. It’s imperative we gain balance within, so all our systems within us work well, it doesn’t seem like Rocket Science – but it gets tricky so hang on for the ride as I plan on continuing this education for quite some time in future articles.

As we continue to study the ECS and its myriad influences on human health, it becomes increasingly clear that balance is not just a concept but a physiological state everyone should harness for therapeutic benefit.

Understanding and supporting your Endocannabinoid tone as you learn and exercise ECS Balance Control can unlock the potential to feel and live better.

(Reprints of our blog are allowed with proper linkback to this website)

Just a few of the References:

Lu, H.-C., & Mackie, K. (2021). Review of the Endocannabinoid System. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(6), 607–615. DOI.

Lu, H.-C., & Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, 79(7), 516–525. DOI.

Ligresti, A., De Petrocellis, L., & Di Marzo, V. (2016). From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology. Physiological Reviews, 96(4), 1593–1659. DOI.

Mackie, K. (2008). Signaling via CNS cannabinoid receptors. Molecular and Cellular Endocrinology, 286(1-2 Suppl 1), S60–S65. DOI.

Karimian Azari, E., Kerrigan, A., & O’Connor, A. (2020). Naturally Occurring Cannabinoids and their Role in Modulation of Cardiovascular Health. Journal of Dietary Supplements, 17(5), 625–650. DOI